110353 May 2026

: It is strictly contraindicated in children under 12 years of age and in children under 18 following surgeries like tonsillectomies due to the risk of fatal respiratory depression.

-receptor sites. It does not bind to or inactivate histamine itself but prevents it from causing allergic responses.

Topic is a reference number for the drug Chlorpheniramine Polistirex/Codeine Polistirex , better known by its trade name Tuxarin ER . This extended-release medication is primarily used for the relief of cough and upper respiratory symptoms associated with allergies or the common cold. Therapeutic and Pharmacologic Classification 110353

: Crushing, chewing, or snorting the extended-release product can lead to an uncontrolled delivery of codeine, which may result in a fatal overdose.

: Works by antagonizing the effects of histamine at H1cap H sub 1 : It is strictly contraindicated in children under

: Assess respiratory rate, pulse, and blood pressure before and during administration. If the respiratory rate drops below 10 per minute, the patient should be checked for sedation and respiratory depression.

: Acts directly on the cough center in the brain to suppress the cough reflex. Key Assessment & Safety Monitoring Topic is a reference number for the drug

: Because opioids can cause significant constipation, bowel function should be routinely monitored. Patients are often encouraged to increase fluid and fiber intake or use stimulant laxatives if treatment exceeds 2–3 days. Contraindications and Risks