A New Era at Seattle Grace: "A Change Is Gonna Come" The Season 4 premiere of Grey's Anatomy , titled serves as a pivotal "reboot" for the series. Airing originally on September 27, 2007, it transitions the core cast from interns to residents, fundamentally shifting the power dynamics at Seattle Grace Hospital. Plot Summary: Residents, Interns, and a Deer

In one of the show's more unusual storylines, Izzie Stevens risks her professional reputation by attempting to save a dying deer brought in by a young boy, much to the confusion of her new interns. Core Themes and Character Shifts

Among the new interns is Lexie Grey (played by Chyler Leigh), Meredith’s half-sister whom she has never met, and George O'Malley , who is forced to repeat his intern year after failing his exams.

The episode picks up seventeen days after the Season 3 finale. Meredith, Cristina, Izzie, and Alex are now with interns of their own to mentor—a task they find as daunting as it is exciting.

In a surprising move, Richard Webber appoints Callie Torres as Chief Resident, bypassing the more experienced and expectant Miranda Bailey.

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