Antifungal Agent -

: Azoles inhibit the cytochrome P450-dependent enzyme lanosterol

: This binding creates physical pores or channels in the membrane. Small essential molecules and cellular organelles leak out of these pores, causing cell death. Common Examples : Amphotericin B, nystatin , and natamycin. 3. Echinocandins antifungal agent

: Blocking this enzyme leads to ergosterol depletion and the accumulation of toxic methylated sterols, ultimately altering membrane function and stopping growth. and voriconazole .

: Fluconazole , itraconazole , and voriconazole . 2. Polyenes antifungal agent

To combat fungal infections safely, medical science targets biological structures and pathways that are unique to fungi. Modern antifungal agents are primarily categorized into four major classes based on their specific mechanisms:

: This blocks an early step in ergosterol biosynthesis, leading to a toxic buildup of squalene and depletion of ergosterol. Common Examples : Terbinafine. Antifungal Agents - StatPearls - NCBI Bookshelf - NIH