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: It is "likely effective" for treating thinning vaginal tissue (vaginal atrophy) in postmenopausal women. FDA-approved vaginal inserts are available for this purpose.

: It may improve mood and libido in women with primary or secondary adrenal insufficiency who still feel unwell despite standard hormone replacement. Quality and Purchasing Considerations buy dhea supplement

DHEA is most effective when treating documented hormone deficiencies or specific medical issues rather than as a general wellness supplement: : It is "likely effective" for treating thinning

Because DHEA is a hormone, quality control is critical. Over-the-counter (OTC) products often vary significantly in potency, sometimes containing 0% to 150% of the labeled amount. DHEA - Mayo Clinic Quality and Purchasing Considerations DHEA is most effective

: Some evidence indicates it may be "possibly effective" for improving mood in people with low DHEA levels, though it is not a first-line therapy.