The "next generation" of cerebral amyloid angiopathy (CAA) diagnosis is defined by the , released in late 2022 to replace the 2010 modified criteria. This update shifts the diagnostic paradigm from purely hemorrhagic markers to a more holistic "small vessel disease" profile, integrating white matter signatures. Key Evolutions in the Next Generation Criteria
The v2.0 criteria significantly increase diagnostic sensitivity—capturing more true cases without losing specificity—by broadening the biological markers recognized by MRI. The "next generation" of cerebral amyloid angiopathy (CAA)
: For the first time, white matter characteristics are part of the formal criteria. A diagnosis of probable CAA can now be made with just one lobar hemorrhagic lesion if accompanied by either: The "next generation" of cerebral amyloid angiopathy (CAA)
: Enlarged fluid spaces in the deep white matter. The "next generation" of cerebral amyloid angiopathy (CAA)