[s5e22] What A Difference A Day Makes «HIGH-QUALITY PACK»

: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts

: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to. [S5E22] What a Difference a Day Makes

While the wedding takes center stage, the hospital remains in chaos due to a tragic car crash involving college students on their way to graduation. : Jeffrey Dean Morgan makes a final appearance

: George O'Malley faces an emotional crisis when almost all the students from the accident die under his care, leaving him devastated until Owen Hunt helps him see the lives he did save. : George O'Malley faces an emotional crisis when

: After Derek and Bailey discover that Izzie has an inoperable brain tumor, the group decides to celebrate her life and love immediately.

: Despite the shift in plans, the wedding remains a fan favorite, featuring the original "MAGIC" interns (Meredith, Alex, George, Izzie, and Cristina) as the wedding party.