Utilizes a deformable mirror to correct for system-level nonlinearities and optical aberrations, enabling sharp imaging across the entire 50 mm² area.
The system sequences through Zernike modes to compensate for aberrations, with optimization processes sometimes completing in minutes, tailored for high-speed scanning (e.g., 133 Hz for ROI). VAM_GS.Qiao.2.var
Employs advanced scanning techniques to achieve a total imaged volume of over 45 mm³. 3. Key Applications in Neuroscience Utilizes a deformable mirror to correct for system-level
The system described in the 2026 publications (often referred to as the ULTRA system) provides an unprecedented combination of field-of-view (FOV) and depth. Multi-scale in vivo neuronal imaging. It achieves cellular resolution across an ultra-large FOV
It achieves cellular resolution across an ultra-large FOV exceeding 50 mm².
The ULTRA system is specifically designed for complex, multi-regional brain studies.
The system produces large, dense 3D datasets requiring advanced denoising, sometimes utilizing "zero-shot learning" methods to process weak fluorescence signals without pre-training on existing data. Summary of Performance (2026) Capability Field of View Imaging Depth Spatial Range Volume Coverage Resolution Cellular resolution
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